According to the documentation for the SharePoint 2010 SDK, you cannot trigger Audience compilation programmatically. Well—that's not true. It isn't documented, but it is possible. The painful thing about it is that you must know the …
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Programmatically compile Audiences in SharePoint 2010
Help! KB932091 broke my SharePoint installation!
Well, it broke ours, too. Our root site collection was completely inaccessible, and the main SharePoint site was returning an HTTP status code of 500. After 12 solid hours of wild goose chases tracking down erroneous error messages, we …